How BGR-34 works?
BGR-34 is a novel, natural DPP-4 inhibitor and unlike other modern DPP-4 inhibitors, it regulates blood glucose level and also exerts cardio-protective action. BGR-34 modulates insulin release & strengthens β-cell functional capacity. It also exerts powerful anti-oxidant action which prevents the development of diabetic complications.
Improves Insulin action by activating AMPK
Berberine from has been shown to have a significant beneficial effect on diabetes mellitus type-2, and may be as effective as metformin (500 mg /day). Berberine acts through several mechanisms, including insulin mimicking action, improving insulin action by activating AMPK, reducing insulin resistance through protein kinase C-dependent upregulation of insulin receptor expression inducing glycolysis, and on incretins by promoting GLP-1 secretion and modulating its release, by inhibiting DPP-4.
Increases insulin secretion and improves oral glucose tolerance
Berberine from Berberis aristata (Daruharidra) has been shown to antagonize the hyperglycaemic action of glucose and the gluconeogenic action of alanine in experimental subjects and on hepatocyte cell lines. It seems to decrease insulin resistance by raising insulin sensitivity. The could explain the anti-diabetic activity of berberine including the decrease of fasting blood glucose level, the increase in insulin secretion and the improvement in oral glucose tolerance tests (OGTT) was observed in experimental subjects.